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連続流動中の高せん断応力で結晶品質を向上
滝山研究室は、反応性結晶化中の結晶粒子の品質を向上させる新しい方法を開発しました。テイラー渦流と呼ばれる高せん断応力を伴う連続流動を使用することで、相図上の異なる操作点が結晶品質にどのように影響するかを研究しました。この方法は、一貫した条件を維持し、粒子の凝集を防ぐのに役立ちます。
研究では、溶液のpHや過飽和度などの要因が結晶のアスペクト比（縦横の比率を表す指標）やサイズ分布に大きく影響することがわかりました。これらの要因を考慮した操作戦略を慎重に設計することで、より高品質な結晶粒子を生成することができました。このアプローチは、操作点と結晶品質の関係を明確にし、結晶化プロセスを改善するための有望な戦略を提供します。
Enhancing Crystal Quality with High Shear Stress in Continuous Flow
Takiyama Research Group has developed a new method to improve the quality of crystalline particles during reactive crystallization. By using a continuous flow with high shear stress, known as Taylor vortex flow, they were able to study how different operation points on the phase diagram affect crystal quality. This method helps to maintain consistent conditions and prevent particle agglomeration.
The study found that factors like solution pH and supersaturation significantly impact the aspect ratio and size distribution of the crystals. By carefully designing an operation strategy that considers these factors, the researchers were able to produce higher quality crystalline particles. This approach clarifies the relationship between operation points and crystal quality, offering a promising strategy for improving crystallization processes.
Investigating the effect of operation points on crystal quality in reactive crystallization using continuous flow with high shear stress
Shuntaro Amari, Chinami Sugawara, Ryo Harada, Shoji Kudo, Hiroshi Takiyama
https://doi.org/10.1016/j.cherd.2021.09.030
Highlights
•Crystal quality for reactive crystallization is studied using continuous process.
•Continuous flow with high shear stress is employed to efficiently mix feed solutions.
•Effect of operation points on crystal quality is revealed using a continuous process.