{"id":5491,"date":"2025-02-14T13:45:23","date_gmt":"2025-02-14T04:45:23","guid":{"rendered":"https:\/\/tuat-chemphys.net\/?p=5491"},"modified":"2025-03-03T09:24:34","modified_gmt":"2025-03-03T00:24:34","slug":"phd-%e5%85%ac%e8%81%b4%e4%bc%9a-improving-dissolution-performance-of-active-pharmaceutical-ingredient-apl-by-nucleation-enhancement-phenomenon-%e6%a0%b8%e5%8c%96%e4%bf%83%e9%80%b2%e7%8f%be%e8%b1%a1","status":"publish","type":"post","link":"https:\/\/tuat-chemphys.net\/?p=5491","title":{"rendered":"PhD \u516c\u8074\u4f1a Dissolution Performance of &#8220;Pharmaceutical Ingredient&#8221; by Nucleation Enhancement \u6838\u5316\u4fc3\u9032\u3067\u539f\u85ac\u306e\u6eb6\u89e3\u6027\u306e\u6539\u5584 (2025\/2\/17)"},"content":{"rendered":"\n<p>2024\/2\/17\uff08\u6708\uff09 10:30<br>TUMURBAATAR\u3000BOLOR-UYANGA\u30004\u53f7\u9928336\u5ba4\uff1a\u4ea4\u6d41\u30b9\u30da\u30fc\u30b9<\/p>\n\n\n\n<p><br>Development of Multi-Phase Solid Formation Method for Improving Dissolution Performance of APl (Active Pharmaceutical Ingredient) Using Nucleation Enhancement Phenomenon \u6838\u5316\u4fc3\u9032\u73fe\u8c61\u3092\u5229\u7528\u3057\u305f\u539f\u85ac\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u8907\u76f8\u56fa\u4f53\u88fd\u9020\u6cd5\u306e\u958b\u767a<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u6982\u8981\uff1a\u672c\u7814\u7a76\u306f\u3001\u7d50\u6676\u6027\u533b\u85ac\u54c1\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u591a\u6210\u5206\u56fa\u4f53\u306e\u88fd\u9020\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u65b9\u6cd5\u306f\u6df7\u548c\u7cfb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u3053\u308c\u3092\u6df7\u548c\u3057\u306a\u3044\u7cfb\u306b\u62e1\u5f35\u3059\u308b\u3053\u3068\u3092\u63a2\u6c42\u3057\u307e\u3057\u305f\u3002\u4e3b\u306a\u6210\u679c\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<p>\uff08\uff11\uff09\u5c40\u6240\u904e\u98fd\u548c\u3092\u5229\u7528\u3057\u3066\u6838\u5316\u4fc3\u9032\u3092\u9054\u6210\u3057\u3001\u6838\u5316\u5bc6\u5ea6\u3092\u5897\u52a0\u3055\u305b\u3001\u7d50\u6676\u7c92\u5b50\u3092\u7cbe\u88fd\u3057\u307e\u3057\u305f\u3002<br>\uff08\uff12\uff09\u6df7\u548c\u3057\u306a\u3044\u7cfb\u304b\u3089\u8907\u76f8\u56fa\u4f53\u3092\u88fd\u9020\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3001\u6838\u5316\u4fc3\u9032\u3068\u526a\u65ad\u529b\u3092\u901a\u3058\u3066\u6eb6\u89e3\u6027\u3068\u69cb\u9020\u3092\u6539\u5584\u3057\u307e\u3057\u305f\u3002<br>\uff08\uff13\uff09\u9ad8\u85ac\u7269\u8ca0\u8377\u6761\u4ef6\u4e0b\u3067\u3082\u6eb6\u89e3\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u591a\u5b54\u8cea\u8907\u76f8\u56fa\u4f53\u3092\u7814\u7a76\u3057\u3001\u6c17\u5b54\u5316\u3068\u526a\u65ad\u529b\u3092\u5229\u7528\u3057\u3066\u5b54\u69cb\u9020\u3068\u5fae\u7d30\u306a\u7d50\u6676\u7c92\u5b50\u3092\u5f62\u6210\u3057\u307e\u3057\u305f\u3002<br>\u672c\u8ad6\u6587\u306f\u3001\u6838\u5316\u4fc3\u9032\u73fe\u8c61\u3092\u5229\u7528\u3057\u3066\u3001\u6df7\u548c\u3057\u306a\u3044\u7cfb\u304b\u3089API\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u8907\u76f8\u56fa\u4f53\u3092\u88fd\u9020\u3059\u308b\u65b9\u6cd5\u3092\u63d0\u6848\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>This research focuses on improving the dissolution of crystalline pharmaceuticals by producing multi-component solids. Traditional methods often use miscible systems, but this study explores extending these methods to immiscible systems.<\/p>\n\n\n\n<p>Key findings include:<\/p>\n\n\n\n<p>1: Achieved nucleation enhancement using local supersaturation, increasing nucleation density and refining crystalline particles.<br>2: Developed a method for producing multi-phase solids from immiscible systems, improving dissolution and structure through nucleation enhancement and shear force.<br>3: Investigated porous multi-phase solids to enhance dissolution even under high drug loading conditions, using aeration and shear force to create pore structures and fine crystalline particles.<br>This thesis proposes a method to produce multi-phase solids from immiscible systems, improving API ()dissolution through nucleation enhancement..<\/p>\n\n\n\n<p>RELATED PUBLICATIONS<\/p>\n\n\n\n<p>Tumurbaatar, B. -U., S. Amari and H. Takiyama, &#8220;The Effect of Template Reset Operation on the Number of Crystals Precipitated at the Air\u2013Solution Template Interface,&#8221; Crystals, 14, 591 (2024).<\/p>\n\n\n\n<p>Tumurbaatar, B. -U. and H. Takiyama, &#8220;Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt,&#8221; Journal of Chemical Engineering of Japan, 58, 1, 2461078 (2025).<\/p>\n\n\n\n<p>Tumurbaatar, B. -U., S. Amari and H. Takiyama, &#8220;Dissolution performance enhancement of poorly water-soluble API by crystallization from phase-separated melt,&#8221; Chemical Engineering Research and Design, 203, 538-546 (2024).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"810\" height=\"286\" data-attachment-id=\"5495\" data-permalink=\"https:\/\/tuat-chemphys.net\/?attachment_id=5495\" data-orig-file=\"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg.jpg?fit=2213%2C782&amp;ssl=1\" data-orig-size=\"2213,782\" data-comments-opened=\"0\" 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Intro \u7814\u7a76\u5ba4\u7d39\u4ecb","link":"https:\/\/tuat-chemphys.net\/?cat=6"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/04\/Gemini_Generated_Image_tnsv0ctnsv0ctnsv.png?fit=1200%2C655&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/04\/Gemini_Generated_Image_tnsv0ctnsv0ctnsv.png?fit=1200%2C655&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/04\/Gemini_Generated_Image_tnsv0ctnsv0ctnsv.png?fit=1200%2C655&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/04\/Gemini_Generated_Image_tnsv0ctnsv0ctnsv.png?fit=1200%2C655&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/04\/Gemini_Generated_Image_tnsv0ctnsv0ctnsv.png?fit=1200%2C655&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":7013,"url":"https:\/\/tuat-chemphys.net\/?p=7013","url_meta":{"origin":5491,"position":2},"title":"\u5b66\u751f\u304c\u3001\u56fd\u5185\u5916\u306e\u5b66\u4f1a\u3084\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3067\u591a\u6570\u306e\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f Students have received numerous awards at national and international conferences in 2025.","author":"unet","date":"2025-12","format":false,"excerpt":"Students have received numerous awards at national and international conferences in 2025. Here are the highlights:","rel":"","context":"In &quot;Awards&quot;","block_context":{"text":"Awards","link":"https:\/\/tuat-chemphys.net\/?cat=3"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/12\/image-2.png?fit=732%2C313&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/12\/image-2.png?fit=732%2C313&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/12\/image-2.png?fit=732%2C313&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/12\/image-2.png?fit=732%2C313&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":6613,"url":"https:\/\/tuat-chemphys.net\/?p=6613","url_meta":{"origin":5491,"position":3},"title":"Our presentations: \u30a8\u30cd\u30eb\u30ae\u30fc\u5b66\u4f1a\u3001\u5fdc\u7528\u7269\u7406\u5b66\u4f1a\u3001\u96fb\u5b50\u60c5\u5831\u901a\u4fe1\u5b66\u4f1a\u3001\u96fb\u6c17\u5b66\u3001\u5316\u5b66\u5de5\u5b66\u4f1a\u3001\u7269\u7406\u5b66\u4f1a\u7b49","author":"unet","date":"2025-08","format":false,"excerpt":"At Japan Institute of Energy, Society of Applied Physics, IEICE Society Conference, Soc. Chemical Engineers, Physical Society of Japan, etc.","rel":"","context":"In &quot;Event\/News&quot;","block_context":{"text":"Event\/News","link":"https:\/\/tuat-chemphys.net\/?cat=4"},"img":{"alt_text":"Earth Day Presentation","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/08\/3468651131_cd3427b484_b.jpg?fit=1023%2C432&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/08\/3468651131_cd3427b484_b.jpg?fit=1023%2C432&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/08\/3468651131_cd3427b484_b.jpg?fit=1023%2C432&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/08\/3468651131_cd3427b484_b.jpg?fit=1023%2C432&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":7231,"url":"https:\/\/tuat-chemphys.net\/?p=7231","url_meta":{"origin":5491,"position":4},"title":"\u30d3\u30b9\u30ea\u7814\u306e\u5b66\u751f\u304c\u56fd\u969b\u4f1a\u8b70\u3067\u6210\u679c\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002Bisri Lab Students with Seven Poster Presentations at CEMS International Symposium on Supramolecular Chemistry and Functional Materials 2026","author":"unet","date":"2026-02","format":false,"excerpt":"Bisri\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b3\u30ed\u30a4\u30c9\u91cf\u5b50\u30c9\u30c3\u30c8\u3001\u534a\u5c0e\u4f53\u30ca\u30ce\u7d50\u6676\u3001\u305d\u3057\u3066\u6a5f\u80fd\u6027\u6750\u6599\u3092\u7528\u3044\u305f\u6b21\u4e16\u4ee3 optoelectronics\uff08\u5149\u96fb\u5b50\u30c7\u30d0\u30a4\u30b9\uff09\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002","rel":"","context":"In &quot;Event\/News&quot;","block_context":{"text":"Event\/News","link":"https:\/\/tuat-chemphys.net\/?cat=4"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/02\/image.png?fit=933%2C424&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/02\/image.png?fit=933%2C424&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/02\/image.png?fit=933%2C424&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/02\/image.png?fit=933%2C424&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":6895,"url":"https:\/\/tuat-chemphys.net\/?p=6895","url_meta":{"origin":5491,"position":5},"title":"\u30e9\u30dc\u30ed\u30fc\u30c6\u30fc\u30b7\u30e7\u30f3\u5236\u5ea6 Lab Rotation Program 1~2\u5e74\u751f\u306e\u5168\u5b66\u751f","author":"unet","date":"2025-10","format":false,"excerpt":"\u7814\u7a76\u306b\u65e9\u304f\u304b\u3089\u89e6\u308c\u3066\u307f\u305f\u3044\u3068\u3044\u3046\u610f\u6b32\u7684\u306a\u5b66\u751f\u306e\u305f\u3081\u306b\u300c\u30e9\u30dc\u30ed\u30fc\u30c6\u30fc\u30b7\u30e7\u30f3\u5236\u5ea6\u300d\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002 a \u201cLab Rotation Program\u201d for motivated students who want to experience research early in their academic journey.","rel":"","context":"In &quot;Event\/News&quot;","block_context":{"text":"Event\/News","link":"https:\/\/tuat-chemphys.net\/?cat=4"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2025\/10\/image-6-300x141.png?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"jetpack_shortlink":"https:\/\/wp.me\/pa3J4g-1qz","jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/posts\/5491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5491"}],"version-history":[{"count":10,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/posts\/5491\/revisions"}],"predecessor-version":[{"id":5646,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/posts\/5491\/revisions\/5646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=\/wp\/v2\/media\/5495"}],"wp:attachment":[{"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tuat-chemphys.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}