{"id":5491,"date":"2025-02-14T13:45:23","date_gmt":"2025-02-14T04:45:23","guid":{"rendered":"https:\/\/tuat-chemphys.net\/?p=5491"},"modified":"2025-03-03T09:24:34","modified_gmt":"2025-03-03T00:24:34","slug":"phd-%e5%85%ac%e8%81%b4%e4%bc%9a-improving-dissolution-performance-of-active-pharmaceutical-ingredient-apl-by-nucleation-enhancement-phenomenon-%e6%a0%b8%e5%8c%96%e4%bf%83%e9%80%b2%e7%8f%be%e8%b1%a1","status":"publish","type":"post","link":"https:\/\/tuat-chemphys.net\/?p=5491","title":{"rendered":"PhD \u516c\u8074\u4f1a Dissolution Performance of &#8220;Pharmaceutical Ingredient&#8221; by Nucleation Enhancement \u6838\u5316\u4fc3\u9032\u3067\u539f\u85ac\u306e\u6eb6\u89e3\u6027\u306e\u6539\u5584 (2025\/2\/17)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">2024\/2\/17\uff08\u6708\uff09 10:30<br>TUMURBAATAR\u3000BOLOR-UYANGA\u30004\u53f7\u9928336\u5ba4\uff1a\u4ea4\u6d41\u30b9\u30da\u30fc\u30b9<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Development of Multi-Phase Solid Formation Method for Improving Dissolution Performance of APl (Active Pharmaceutical Ingredient) Using Nucleation Enhancement Phenomenon \u6838\u5316\u4fc3\u9032\u73fe\u8c61\u3092\u5229\u7528\u3057\u305f\u539f\u85ac\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u8907\u76f8\u56fa\u4f53\u88fd\u9020\u6cd5\u306e\u958b\u767a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6982\u8981\uff1a\u672c\u7814\u7a76\u306f\u3001\u7d50\u6676\u6027\u533b\u85ac\u54c1\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u591a\u6210\u5206\u56fa\u4f53\u306e\u88fd\u9020\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u65b9\u6cd5\u306f\u6df7\u548c\u7cfb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u3053\u308c\u3092\u6df7\u548c\u3057\u306a\u3044\u7cfb\u306b\u62e1\u5f35\u3059\u308b\u3053\u3068\u3092\u63a2\u6c42\u3057\u307e\u3057\u305f\u3002\u4e3b\u306a\u6210\u679c\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\uff11\uff09\u5c40\u6240\u904e\u98fd\u548c\u3092\u5229\u7528\u3057\u3066\u6838\u5316\u4fc3\u9032\u3092\u9054\u6210\u3057\u3001\u6838\u5316\u5bc6\u5ea6\u3092\u5897\u52a0\u3055\u305b\u3001\u7d50\u6676\u7c92\u5b50\u3092\u7cbe\u88fd\u3057\u307e\u3057\u305f\u3002<br>\uff08\uff12\uff09\u6df7\u548c\u3057\u306a\u3044\u7cfb\u304b\u3089\u8907\u76f8\u56fa\u4f53\u3092\u88fd\u9020\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3001\u6838\u5316\u4fc3\u9032\u3068\u526a\u65ad\u529b\u3092\u901a\u3058\u3066\u6eb6\u89e3\u6027\u3068\u69cb\u9020\u3092\u6539\u5584\u3057\u307e\u3057\u305f\u3002<br>\uff08\uff13\uff09\u9ad8\u85ac\u7269\u8ca0\u8377\u6761\u4ef6\u4e0b\u3067\u3082\u6eb6\u89e3\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u591a\u5b54\u8cea\u8907\u76f8\u56fa\u4f53\u3092\u7814\u7a76\u3057\u3001\u6c17\u5b54\u5316\u3068\u526a\u65ad\u529b\u3092\u5229\u7528\u3057\u3066\u5b54\u69cb\u9020\u3068\u5fae\u7d30\u306a\u7d50\u6676\u7c92\u5b50\u3092\u5f62\u6210\u3057\u307e\u3057\u305f\u3002<br>\u672c\u8ad6\u6587\u306f\u3001\u6838\u5316\u4fc3\u9032\u73fe\u8c61\u3092\u5229\u7528\u3057\u3066\u3001\u6df7\u548c\u3057\u306a\u3044\u7cfb\u304b\u3089API\u306e\u6eb6\u89e3\u6027\u3092\u6539\u5584\u3059\u308b\u8907\u76f8\u56fa\u4f53\u3092\u88fd\u9020\u3059\u308b\u65b9\u6cd5\u3092\u63d0\u6848\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This research focuses on improving the dissolution of crystalline pharmaceuticals by producing multi-component solids. Traditional methods often use miscible systems, but this study explores extending these methods to immiscible systems.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Key findings include:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1: Achieved nucleation enhancement using local supersaturation, increasing nucleation density and refining crystalline particles.<br>2: Developed a method for producing multi-phase solids from immiscible systems, improving dissolution and structure through nucleation enhancement and shear force.<br>3: Investigated porous multi-phase solids to enhance dissolution even under high drug loading conditions, using aeration and shear force to create pore structures and fine crystalline particles.<br>This thesis proposes a method to produce multi-phase solids from immiscible systems, improving API ()dissolution through nucleation enhancement..<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RELATED PUBLICATIONS<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tumurbaatar, B. -U., S. Amari and H. Takiyama, &#8220;The Effect of Template Reset Operation on the Number of Crystals Precipitated at the Air\u2013Solution Template Interface,&#8221; Crystals, 14, 591 (2024).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tumurbaatar, B. -U. and H. Takiyama, &#8220;Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt,&#8221; Journal of Chemical Engineering of Japan, 58, 1, 2461078 (2025).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tumurbaatar, B. -U., S. Amari and H. Takiyama, &#8220;Dissolution performance enhancement of poorly water-soluble API by crystallization from phase-separated melt,&#8221; Chemical Engineering Research and Design, 203, 538-546 (2024).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"362\" data-attachment-id=\"5495\" data-permalink=\"https:\/\/tuat-chemphys.net\/?attachment_id=5495\" data-orig-file=\"https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg.jpg\" data-orig-size=\"2213,782\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"1-s2.0-S0263876224000923-ga1_lrg\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-1024x362.jpg\" src=\"https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-1024x362.jpg\" alt=\"\" class=\"wp-image-5495\" srcset=\"https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-1024x362.jpg 1024w, https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-300x106.jpg 300w, https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-768x271.jpg 768w, https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-1536x543.jpg 1536w, https:\/\/tuat-chemphys.net\/wp-content\/uploads\/2025\/02\/1-s2.0-S0263876224000923-ga1_lrg-2048x724.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>2024\/2\/17\uff08\u6708\uff09 10:30TUMURBAATAR\u3000BOLOR-UYANGA\u30004\u53f7\u9928336\u5ba4\uff1a\u4ea4\u6d41\u30b9\u30da\u30fc\u30b9 Development of Multi-Phase Solid Formation Method for Improving Dissolution Performance of APl (Active Pharmaceutical Ingredient) Using Nucleation Enhancement<\/p>\n","protected":false},"author":1,"featured_media":5495,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[22],"tags":[14],"class_list":["post-5491","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-doctoral-thesis-","tag-advanced-materials-creation"],"jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":8118,"url":"https:\/\/tuat-chemphys.net\/?p=8118","url_meta":{"origin":5491,"position":0},"title":"\u300c\u6cb9\u6ef4\u300d\u306e\u306a\u304b\u3067\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\uff1f\u30aa\u30a4\u30eb\u30a2\u30a6\u30c8\u6cd5\u3067\u7d50\u6676\u306e\u5927\u304d\u3055\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30ebWhat happens inside the &#8220;oil droplet&#8221;? Controlling crystal size using the oil-out method.","author":"edit","date":"2026-08","format":false,"excerpt":"\u6db2\u4f53\u306e\u5206\u96e2\u304c\u751f\u307f\u51fa\u3059\u3001\u7279\u7570\u306a\u6eb6\u6db2\u7d44\u6210\u3068\u64cd\u4f5c\u6761\u4ef6\u306e\u5f71\u97ff\u3068\u306fWhat are the effects of the unique solution composition and operating conditions resulting from liquid-liquid phase separation? \u25a0\u80cc\u666f\u3068\u554f\u984c\u610f\u8b58 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via oiling-out\" Characterization of Crystal Particles Utilizing the Oil-Out Phenomenon\u2026","rel":"","context":"In &quot;Research Topics&quot;","block_context":{"text":"Research Topics","link":"https:\/\/tuat-chemphys.net\/?cat=9"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/08\/Gemini_Generated_Image_l2ud3sl2ud3sl2ud.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/08\/Gemini_Generated_Image_l2ud3sl2ud3sl2ud.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/08\/Gemini_Generated_Image_l2ud3sl2ud3sl2ud.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/tuat-chemphys.net\/wp-content\/uploads\/2026\/08\/Gemini_Generated_Image_l2ud3sl2ud3sl2ud.png?resize=700%2C400&ssl=1 2x, 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